CONCLUSION The stability of tetanus toxoid loaded microspheres was satisfactory.The optimized tetanus toxoid containing microspheres may be valuable for a controlled vaccine delivery system.

• 结论 破伤风类毒素聚乳酸微球中的蛋白质在制备过程和体内酸性环境中基本稳定，聚乳酸微球可望发展成为疫苗控释系统。