CONCLUSION The interferon combined with thymopeptide alpha1 can effectively break the state of immune-tolerance of HBV carriers and recover the normal immunocompetence of host to HBV.

• 结论 两药联用是HBV-DNA阴转率及HBeAg血清转换率近、远期疗效均明显优于对照组，它能使部分患者转氨酶升高而脱离免疫耐受，还可通过自身免疫清除体内的乙肝病毒。