CML typically starts with an indolent chronic phase followed by an aggressive myeloid or lymphoid blast crisis phase, which is dependent on the constitutive kinase activity of the BCR-ABL oncoprotein.

• 依赖于BCR-ABL融和基因表达的激酶活性，CML患者通常有一个稳定的慢性期随后进入髓变或淋变的加速期。