CIK cells can down regulate the expression of P glycoprotein in MCF7 adr cell line remarkably, and synergistic cytotoxic effect against MCF7 adr cell line can be detected when combined with ADR.

• CIK细胞可明显抑制MCF7adr肿瘤细胞系的P gp表达 ,可协同阿霉素提高对MCF7adr肿瘤细胞系的杀伤活性。