CCAM is thought to result from a failure of the pulmonary mesenchyme to induce normal bronchoalveolar differentiation in a part of the fetal lung between the fifth and seventh weeks of gestation.

• 其中先天囊肿性腺瘤样畸形目前被认为是肺间质在妊娠5到7周时无法成功的诱发部分胎儿支气管肺泡的分化所致。