C57BL/6 mice were immunized intramuscularly every 2 weeks for 3 times with pcDNA3.0-backbone recombinant plasmids of Hantaan virus 84Fli that encoded the NP and GP proteins,and contrasted with bivalent inactivated EHF vaccine.

 
  • 为了加强我国病毒性出血热的防治;本研究将汉滩病毒84Fli株核蛋白S和糖蛋白M编码片段分别克隆至pcDNA3.;0载体;构建了pcDNA3/84S和pcDNA3/84M重组质粒;等量混合采用肌肉注射途径免疫C57BL/6小鼠;免疫3次;每次间隔2周;同时与双价出血热病毒灭活疫苗进行对比。
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