Both 18C-TT and 19F-TT induced immunological memory responses in mice. The induced IgG showed good affinity and complement-depen-dent opsonophagocity, and could clear the infection of streptococcus pneumonae effectively.

• 18C-TT和19F-TT免疫小鼠后,能有效地产生再次免疫应答,其IgG有良好的亲和力和补体依赖的调理吞噬功能,能有效地清除肺炎链球菌的感染。