Blockage of costimulatory signal CD86 at the early stage of gestation can induce the reduction of the ratio of MMP-9/TIMP-3 by some mechanisms and reduce the embryo resorption rate in the abortion-prone model to that of normal pregnant level.

• 在妊娠早期阻断CD86协同刺激分子能够通过某些机制诱导自然流产鼠MMP-9/TIMP-3的比值降低并且降低自然流产模型的胚胎吸收率,使模型组的胚胎吸收率恢复至正常妊娠水平。