Better response at week 48 has significantly higher serum ALT levels and lower HBV DNA levels prior to treatment and HBV DNA negativity at week 24 compared with non-response.

• 慢性乙型肝炎患者应用阿德福韦酯治疗前HBV DNA低水平、ALT高水平且24周时HBV DNA阴转是48周疗效较好的预测指标;