Balsalazide was synthesized from 4-nitrobenzyl chloride via condensation, hydrogenation, diazotization and coupling.The synthetic process was optimized and the total yield was 73.9%.

• 摘要以对-硝基苯甲酰氯为起始原料，经缩合、还原、重氮化、偶合4步反应制得巴柳氮，总收率73.；9%25。