At high magnification, the dermis is expanded by dense collagenous fibrosis in a patient with systemic sclerosis. Immunofluorescence is not helpful with scleroderma.

• 高倍镜下，系统性硬化症病人真皮中胶原纤维增加使皮肤增厚。免疫荧光检测对硬皮病是无用的。注意：近年来我们往往用系统性硬化症取代名词硬皮病。