As the expression of HO-1 induced by 11,12-EET could be blocked by L-NAME, It was indicated that elevated HO-1 was involved in NO-meadiated signal pathway.

• 提示11,12-EET拮抗心肌缺血/再灌注损伤的作用可能与HO-1表达增加有关,且此时HO-1的表达增加至少部分依赖于cNOS的激活。