As TLR (Toll-like receptor) 4 is the major signaling receptor for LPS, many investigations have focused on changes in the TLR4 signaling pathways as a mechanism of endotoxin tolerance.

• 自从证实TLR (Toll-like receptor) 4是LPS的信号受体以来,内毒素耐受的研究主要集中于信号受体和TLR4胞内信号分子的变化。