As If efflux of lactic acid , the end product of glycolysis, from the cell does not keep pace with production, intracellular concentrations increase and cause the intracellular pH value to decrease .

• 如果乳酸的外运和生成不能同步，乳酸就会在细胞内堆积，从而引起细胞内的pH值下降，导致肿瘤细胞内酸化。