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- The method of HPLC/MS analysis of aristolochic acid A (Aris A A) in Chinese traditional patent medicine(CTPM) was established. 建立了中成药中马兜铃酸A的高效液相色谱/质谱检测方法.
- OBJECTIVE To determine the content of Aristolochic Acid A in different parts of Herba cum Radice Asari and in Xuetie Dingchuan Plaster. 目的测定细辛不同药用部位及其制剂中马兜铃酸A的含量。
- Schmidt ver.Mandshuricum(Maxim.) Kitag contained aristolochic acid A or not by HPLC and MS,and the difference in the reference substance and the sample solution was compared. 方法:采用HPLC与MS分别检测北细辛中的马兜铃酸A,并比较对照品和供试品的检测限。
- RESULT The content of aristolochic acid A in the parts of Herba cum Radice Asari above the ground was higher that in the root part,and aristolochic acid A was not detected in the preparation. 不同药用部位及其制剂定喘穴贴膏中马兜铃酸A的含量。结果细辛地上部分粗粉中马兜铃酸A含量高于细辛根茎粗粉中马兜铃酸A含量,制剂中没有检出马兜铃酸A。
- In this study, we can initially concluded that kidney suffers aristolochic acid A at a certain usage narcotics dose and a certain usage narcotics period, which would lead to nephrotoxicity. 从本课题研究，我们能够得出的初步结论是，马兜铃酸A的肾脏毒性作用，与作用于肾脏组织的染毒剂量和染毒时间有关；
- RESULTS:Aristolochic acid A content in above-ground parts of Herba Asari was higher than that in the root,and aristolochic acid A was not detected ever in some Radix et Rhizoma Asari. 结果:细辛药材根及根茎中不含马兜铃酸A或含量极低,叶中均含马兜铃酸A,含量稍高。
- Keywords Asarum sieboldii Miq.;aristolochic acid A;HPLC; 华细辛;马兜铃酸;高效液相色谱法;
- Keywords manchurian dutchmanspipe stem;aristolochic acid A;extraction;assaying; 关木通;马兜铃酸A;提取;含量测定;
- THE CONCENTRATION OF ARISTOLOCHIC ACID A IN MANCHURIAN DUTCHMAN WAS REDUCED BY COMPATIBILITY METHED 配伍减低关木通中马兜铃酸A溶出量的研究
- Keywords Asarum heterotropoides Fr. Schmidt var.;mandshuricum （Maxim.） Kitag.;Essential oil;Methyleugenol;,,,Safrole;Aristolochic acid A;Quality control;GC-MS;HPLC; 关键词北细辛;挥发油;甲基丁香酚;黄樟醚;马兜铃酸A;质量控制;气质联用色谱法;高效液相色谱法;
- 7-methoxy aristolochic acid A 7-甲氧基马兜铃酸A
- aristolochic acid A 马兜铃酸A
- RESULTS: Aristolochic acid has nephrotoxicity,alimentary canal toxicity,carcinogenicity,mutagenicity and genotoxicity. 结果:马兜铃酸具有肾毒性、消化道毒性、致癌性、致突变性和基因毒性。
- Object: To compare the content of Aristolochic acid of different parts in Asarum heterotropoides Fr. 目的:比较不同产地不同部位辽细辛中马兜铃酸的痕量。
- Results The main ADR related to aristolochic acid is nephropathy, urothelial cancer being found on some patients. 结果与马兜铃酸有关的不良反应主要为肾损害,部分病例出现尿道上皮癌。
- Cosyns J P,Dehoux J P,Guiot Y.et al.Chronic aristolochic acid toxicity in rabbits:A model of Chinese herbs nephropathy.Kidney Int,2001,59:2164. 文晓彦;郑法雷;高瑞通;等.;马兜铃酸I诱导人肾小管上皮细胞转分化的作用
- Objective: To investigate the urinary carcinoma in patients with aristolochic acid nephropathy (AAN), in order to improve the levels of diagnosis. 摘要目的：探讨马兜铃酸肾病患者伴发泌尿系肿瘤情况，提高认识和诊断水平。
- To analyse the 44 cases of aristolochic acid nephropathy (AAN) in term of pathogeny, clinical symptoms, laboratory results, and some renal pathology. 摘要从近6年收治的肾小管间质性疾病中，筛选出马兜铃酸肾病患者44例。
- Objective:To investigate the urinary carcinoma in patients with aristolochic acid nephropathy(AAN),in order to improve the levels of diagnosis. 目的:探讨马兜铃酸肾病患者伴发泌尿系肿瘤情况,提高认识和诊断水平。
- Method Searching published literatures and website associated with aristolochic acid toxicities both domestic and abroad and analyzing them. 方法通过检索国内外公开发表的文献和各国官方网站,收集与马兜铃酸有关的不良反应病例,分析其安全性。
