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- Protective Antibody Response to Recombinant Fragments of Plasmodium falciparum Apical Membrane Antigen 1 重组表达的恶性疟原虫顶端膜抗原1片段诱导小鼠保护性抗体应答
- Expression and Immunogenicity Evaluation of Ectodomain and Subdomains of Plasmodium berghei Apical Membrane Antigen 1 伯氏疟原虫顶端膜抗原1胞外区及其亚区的表达与免疫保护作用分析
- Keywords Plasmodium falciparum Apical membrane antigen 1 Gene expression Affinity chromatography Protein refolding; 恶性疟原虫;顶端膜抗原-1;基因表达;亲和层析;蛋白质重折叠;
- Apical membrane antigen 1 顶端膜抗原1
- METHODS: Eukaryotic expression vectors pTL 8/apical membrane antigen 1 (AMA 1) (tTA) and pTL 8/AMA 1(rtTA)gene which express trans activator (tTA) or reverse trans activator(rtTA), respectively, and AMA 1 gene of Plasmodium falciparum were constructed. 方法 :首先构建恶性疟原虫顶端膜抗原 1(AMA 1)基因和转录激活因子 (tTA或rtTA)基因的真核表达质粒pTL 8/AMA 1和pTL 8/AMA 1(rtTA) ,并大量制备这两种质粒及表达转录抑制子 (tTS)的质粒pUHS6 1。
- apical membrane antigen 顶膜抗原
- The apical membrane of the epithelial cells is apparently essential. 上皮细胞的顶膜显然是必要的。
- It is primarily caused by inactivating mutations of the SLC12A3 gene encoding the thiazide-sensitive Na-Cl cotransporter (NCC) on the apical membrane of distal convoluted tubule. 临床上症状的差异性很大,多发生于青年及成年人;常见的症状包括嗜盐、夜尿、肌肉无力、疲倦、痉挛等;也有部份的病患是属于意外发现的。
- The Phase I clinical trial tested an antibody called J591, targeted to the prostate specific membrane antigen (PSMA). 特异针对前列腺特异膜抗原(PSMA)的抗体J591已经进入临床I期试验。
- By immunoperoxidase staining, they will also be keratin positive and epithelial membrane antigen positive. 通过免疫过氧化物酶染色可知他们也是角蛋白阳性与上皮膜抗原阳性。
- Although Epithelial Membrane Antigen (EMA) is not a tumor marker, there is great similarity to it, for example, the relative organ specificity. 上皮细胞膜抗原(Epithelial membrane antigen,EMA)虽不属肿瘤标志物范畴,但与肿瘤标志物有许多相近之处,如组织的相对特异性。
- Immunogold labelling technique was used for in situ ultrastructural detection of antibodes 51KD human sperm membrane antigen. 本文应用免疫金标记法,对抗51KD精子膜抗原的抗精子抗体在精子的定位进行了超微结构观察。
- Epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), (CAL), (CK) 17, CK18 and vimentin (VIM) were detected in 58 serous specimens. 结果在58例积液标本中,免疫细胞化学鉴别出恶性积液38例,反应性积液20例。
- Objective To set up a genotyping means of the human platelet antigen of 1 system and study genotyping of platelet antigen 1 system of the donors who donate platelet in our region. 目的:建立人类血小板抗原-1系统的基因分型方法,并对本地区献血小板者进行血小板抗原-1基因分型。
- Objective: To study the possibility for the recovery of oocyte plasma membrane antigen as to produce anti fertilization antibodies. 目的:探讨利用人卵细胞膜抗原制备抗受精抗体的可能性。
- CEA (carcinoembryonic antigen), EMA (epithelial membrane antigen)and keratin-three epithelial tumor markers were applied to be the indexes for this research. 选用癌胚抗原(CEA)、上皮膜抗原(EMA)、角蛋白(keratin)3种上皮性肿瘤标记物作为研究指标,采用免疫组织化学方法观察实验组与对照组定位分布状态。
- The inner cell layers of tubuloglandular components had distinct epithelial features,expressing keratin,carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA). 管腺内层细胞有明显上皮特征,其角蛋白、癌 胚抗原(CEA)及上皮细胞膜抗原(EMA)均阳性,而外层细胞对结蛋白(Desmin,Des)、肌动蛋白 (Actin)、CEA及EMA呈阴性,对波形蛋白(Vimentin,Vim)。
- apical membrane antigen-l(AMA-1) 顶端膜抗原1(AMA-1)
- Platelet and T cell activation antigen 1 (PTA1) was initially reported by Burns in 1985 with the name TLiSA1 (T lineage specific activation antigen 1, TLiSA1 ), and was renamed as PTA1 in 1989 because of its expression on platelet as well. 血小板和T细胞活化抗原1(platelet and T cell activation antigen 1,PTA1)最早在1985年由Bums等发现。 由于其表达于人活化T细胞而被命名为TLiSA1抗原(T lineage specific activation antigen 1,TLiSA1)。
- Poorly differentiated nasopharyngeal carcinoma (SUNE 1) cell line was cultured with Epstein Barr virus (EBV) BHRF1, DNase, thymidine kinase (TK) and nuclear antigen 1 (EBNA1) antisense oligodeoxynucleotide (ASO) for 48 h respectively. 用不同浓度的EB病毒 4种 (BHRF1、DNA酶、核抗原 1及胸苷激酶 )反义寡核苷酸片段 ,(antisenseoligodeoxynucleotide ,ASO)分别与含 10%25胎牛血清或不含胎牛血清的人低分化鼻咽癌细胞株 (SUNE 1)共同培养 4 8h。