Antifilaggrin autoantibodies (AFA) were detected in 39 9%(71/178) of RA patients,and 6 cases of control group,with a specificity of 0 969.AFA were present in 48 4%(15/31) of the early and 29 2% of seronegative RA.

• 178例RA中AFA阳性 71例 ,对RA诊断敏感性 39 9%25 ,特异性 96 9%25。