Antibiotic C1027, a macromolecular peptide with highly potent cytotoxicity to cultured cancer cells, was conjugated to monoclonal antibody 3A_5 and its Fab fragment separately using SPDP as the linker agent.

• 抗人肝癌单克隆抗体(单抗)3A_5用木瓜蛋白酶消化得到Fab片段。