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- Objective To observe the local inflammatory response in injured rabbit brain and Blood Brain Barrier(BBB) permeability and traumatic cerebral edema suppressed by anti IL 8 monoclonal antibodies. 目的 观察抗IL 8单抗对兔脑损伤后脑内炎症反应的抑制作用 ,以及对血脑屏障通透性和创伤性脑水肿的影响 ,探讨颅脑损伤后继发性脑损害新的治疗方法。
- Administration of anti IL 8 monoclonal antibodies in TBI prevented expression of IL 8, reduced the infiltration and accumulation of PMNL,attenuated local inflammation injury,reduced BBB permeability,and attenuated SBI after brain injury. 颅脑损伤后早期给予抗IL 8单抗治疗 ,可抑制IL 8的表达 ,抑制IL 8趋化PMNL的作用 ,减少组织中PMNL的浸润 ,减轻脑损伤后脑内炎症反应 ,降低血脑屏障通透性 ,减轻创伤性脑水肿 ,从而改善继发性脑损害。
- THE PREPARATION AND PRELIMINARY DETERMINATION OF ANTI IL 6 MONOCLONAL ANTIBODY 白细胞介素6单克隆抗体的研制
- IL 6 and IL 8 levels produced by LPMC fro m involved colons were significantly higher than that from uninvolved colons. Ad ding exogenous anti IL 17 MoAb to LPMC from involved colons resulted in dec rease in IL 6 and IL 8 production. 另外 ,UC病变部位LPMC分泌的IL 6和IL 8的水平均明显高于非受累部位的LPMC ,但在培养液中加入抗IL 17单克隆抗体后 ,LPMC细胞IL 6和IL 8的分泌均明显被抑制。
- Methods The effects of anti CD4 human mouse chimeric and mouse derived monoclonal antibody on CD3, PHA, IL 2, proliferation induced by allogenic cells and the propagation of ADCC mediated by these antibodies were observed. 方法 观察CD4人 鼠嵌合抗体和鼠源性单抗对CD3、植物血凝素 (PHA)、白细胞介素 2 (IL 2 )及同种异体细胞诱导增殖的影响 ,以及其介导的抗体依赖性细胞介导的细胞毒性 (ADCC)作用。
- Study on the monoclonal antibody to chlorpyrifos. 抗毒死蜱单克隆抗体的研制。
- Methods Anti human bladder carcinoma cell line BIU 87 monoclonal antibody BDI 1 was labelled with technetium 99m by direct mercaptoethanol reducing method. 方法采用抗人膀胱癌单克隆抗体BDI-1通过2-巯基乙醇直接还原法标记99mTc(99mTc)制备了99mTc-BDI-1。
- The roles of IL 8 were discussed during the onset of asthma. 并对血清IL-8在哮喘发病中的作用进行了初步探讨。
- After pretreatment of anti ICAM 1 and E selectin monoclonal antibody, serum LDH and LAT levels decreased significantly; KBR and ATP content of liver increased. 抗ICAM 1及E selectin单抗预处理可使急性胆管炎大鼠血浆LDH ,ALT水平明显降低 ,KBR及肝组织ATP含量升高。
- An alternative to the costly monoclonal antibody approach. 可替代昂贵的单克隆抗体分析方法。
- Objective: To express Fab fragments of the anti colonic cancer antibody and to compare the antigen binding characteristics between the expressing product and the authentic monoclonal antibody. 目的:在大肠杆菌中表达抗结肠癌抗体Fab片段,比较表达产物和原杂交瘤单克隆抗体的抗原结合特性。
- Results 98% purity was reached through 14F7 monoclonal antibody column, and 95% purity was gained after goat anti human Fab fragment column. But yield ratio of the two affinity columns was low, being 35% and 55%, respectively. 结果3种纯化方法中,14F7单克隆抗体柱纯化的Fab抗体的纯度达98%25左右,Fab抗体柱纯化的Fab抗体的纯度为95%25,但这两种亲和柱的目的蛋白收率都不高,分别为35%25、55%25。
- The quantity of interleukin 8 (IL 8) and fibronectin(FN) in culture supernatants was determined by ELISA. 采用ELISA法检测细胞培养液中白细胞介素 8(IL 8)和纤维连接蛋白 (FN)的蛋白质水平 ;
- The results of detection of specific IgG4 in sera of 173 cerebral cysticercosis patients by dip test using gold labeled anti human IgG4 monoclonal antibody(McAb) were reported and compared with the case CT and MR scans. 应用金标抗人IgG4 McAb 浸测试验检测173 例脑囊虫病患者血清中特异IgG4,并与其脑CT、MR影像分型进行对比分析。
- Plasma endotoxin, serum TNF, IL 6 and IL 8 were detected at different time phase after burn. 并在烧伤后不同时相点测定了血浆内毒素,血清TNF,和血浆白介素-6(IL-6)和血浆白介素-8(IL-8)的含量。
- Measurement of maternal serum IL 8,CRP and WBC is useful for early screening the histological chorioamnionitis,and improving the pregnant prognosis. 检测胎膜早破孕妇母血中的IL 8、CRP及白细胞计数可早期发现组织绒毛膜羊膜炎 ,这对及早处理、改善妊娠预后有重要临床意义
- Objective To develop monoclonal antibody Fab fragments using display technique. 目的 利用噬菌体抗体库技术制备抗甲状旁腺激素相关蛋白 (PTHrP)Fab抗体。
- Methods Immunohistochemistry using PCNA monoclonal antibody PC10 cvere studied. 方法用增殖细胞核抗原(PCNA)单克隆抗体PC10免疫组化研究。
- Compared with the control,leukocyte,LRC,the scores of tubules,IL 1,IL 8 and IL 6 began to increase from 2 h post asphyxia and reached the peak at 24 h post asphyxia. 窒息后复氧 2h开始 ,IL 1、IL 8、IL 6水平及白细胞滞留数升高 ,在 2 4h时达到高峰 ;
- The monoclonal antibodies are aimed at EPF. 本研究制备的EPF单克隆抗体为特异性抗EPF抗体。