Among the five mutations,R413P is common in Japan,Y356X and V399V are centered in north China,and R408W is the most often mutation in Europe and America.

• 上述突变中,R413P以日本人最为常见,Y356X和V399V多集中于我国北方地区,而R408W则是欧美及拉美等国最多见的基因突变。