Although there are negative reports, NSABP B-16 and NSABP B-20 investigation all confirmed the advantage of regimen of AC, CMF combined with Tamoxifen.

• 尽管对三苯氧胺与细胞毒性药物联合应用有否定的研究结论，NSABP B-16试验和NSABP B-20试验分别肯定了AC方案和CMF方案与三苯氧胺联用的优势。