Although studies have been carried out at home and abroad, little is known about its pathogenesis.Among these hypotheses, the desmoglein compensation theory is the most influential.

• 随着免疫学、分子生物学的不断发展，提出更多的发病机制，包括抗体介导的细胞凋亡学说、基底细胞塌陷皱缩假说等。