Allelic loss at the FRA3B site occurs frequently in NPC. This suggests that the region between D3S4103 and D3S4260 may represent a preferential molecular target in nasopharyngeal carcinogenesis.

• FRA3B脆性部位的LOH为鼻咽癌的频发事件,可能参与了鼻咽癌的发生发展,共同缺失区D3S4103-D3S4260可能是其优先作用的分子靶点。