All the reports point to a important role of the LC noradrenergic neurons in the pathophysiology of PD.However, the neuronal activity of the LC in the PD is not known very well.

• 因此，推测LC的NA能神经元可能在PD发病中具有重要作用，但是PD状态下LC神经元自身的活动状态目前尚不清楚。