Alkaline phosphatase and collagen I usually expressed in the early stage of bone development while osteocalcin and bone sialoprotein in the late stage.

• 碱性磷酸酶和I型胶原一般在成骨分化的早期高度表达，而骨钙蛋白和骨涎蛋白则在成骨分化的晚期高度表达。