Aim To observe the hepatotoxic effects induced by Rifampicin (RFP) and Isoniazid (INH) when used alone or in combination on mice.

• 目的观察比较利福平(RFP)与异烟肼(INH)单用及合用对小鼠肝脏的致伤作用,探讨两药合用肝毒性增加的作用机理。