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- Agmatine deiminase 鲱精氨脱亚氨酶
- This paper aims to study the effect of agmatine on pc12 cell line injury. 摘要探讨了胍基丁胺对谷氨酸诱导PC12细胞DNA损伤的影响。
- L-Arginine can be converted to L-citrulline with arginine deiminase which was found in the Streptococcus faecalis. 利用粪链球菌精氨酸脱亚胺酶转化L-精氨酸制备L-瓜氨酸。
- Agmatine is a novel neurotransmitter and/or neuromodulator, which is the endogenic ligand of the imidazoline receptors. 摘要胍丁胺是一种新的神经递质和/或神经调质,是咪唑啉受体的内源性配体。
- To study the effect of agmatine (Agm) on L-type calcium current (ICa-L) in rat ventricular myocytes. 目的:观察胍丁胺(Agm)对大鼠心室肌细胞L-型钙通道电流(I_(Ca-L))的影响.
- Agmatine is a novel neurotransmitter and/or neuromodulator,which is the endogenic ligand of the imidazoline receptors. 胍丁胺是一种新的神经递质和/或神经调质,是咪唑啉受体的内源性配体。
- As an amine and organic cation, agmatine also has much more targets in vivo like the NMDA receptor. 它作为一种阳离子胺类物质,除了咪唑啉受体外,在生物体内还存在多个作用靶点,NMDA受体是其中最重要的作用靶点之一。
- The result of extraction of arginine deiminase(ADI) using reversed micellar system is reported,which provides a method for the purification of arginine deiminase. 报道了用反胶束体系萃取精氨酸脱亚胺酶(ADI)的研究结果,为精氨酸脱亚胺酶的分离纯化提供了一种方法。
- As an amine and organic cation,agmatine also has much more targets in vivo like the NMDA receptor. 它作为一种阳离子胺类物质,除了咪唑啉受体外,在生物体内还存在多个作用靶点,NMDA受体是其中最重要的作用靶点之一。
- The effects of agmatine ( Agm) on the discharges of neurons in CA1 area of hippocampal slices were examined by using extracellular recording technique. 应用细胞外记录单位放电技术,在大鼠海马脑片上观察了胍丁胺(agmatine,Agm)对CA1区神经元放电的影响。
- In our previous work, agmatine was proved to enhance morphine analgesia, inhibit tolerance to and physical dependence on morphine. 胍丁胺是咪唑啉受体的内源性配体,我们和国外实验室先后研究发现胍丁胺增强吗啡镇痛,对抗吗啡耐受及躯体依赖。
- Previous studies showed agmatine, an endogenous I1-imidazoline receptor ligand, prevents morphine dependence, but the mechanism remains unclear. 尽管以前研究表明胍丁胺能够抑制吗啡依赖,但其作用机制尚不明确。
- The hemodynamic effects of intravenous injection of agmatine and their cellular mechanism were investigated in anesthetized rats. 在麻醉大鼠研究静注胍基丁胺(AGM)对血流动力学的影响, 并初步探讨其机制。
- The cardiac electrophysiological effects of agmatine (AGM) were examined in guinea pig papillary muscle using intracellular microelectrode technique. 应用细胞内微电极技术, 观察了胍基丁胺(agmatine, AGM)对豚鼠乳头肌细胞的电生理效应。
- The effect of agmatine (Agm) on vascular tension and the underlying receptor mechanism were investigated in the isolated aortic artery of rats. 采用离体血管环灌流方法, 观察了胍丁胺(agmatine, Agm)对大鼠胸主动脉张力的影响, 并探讨其受体机制。
- In rat CPP model, agmatine (0.75-20 mg/kg, sc) co-administered with morphine inhibited the development, expression and the priming of CPP induced by morphine. 在条件性位置偏爱(CPP)模型上;吗啡处理大鼠9d可形成明显CPP。 胍丁胺(0.;75-20mg/kg;sc)伴随吗啡给药抑制CPP的形成、表达和小剂量吗啡诱导的复发。
- Objective: This study investigates the damage of PC12 cells induced by Glutamate, and the possible neuro-protective effect of agmatine against the cell damage. 目的:研究一定浓度谷氨酸对PC12细胞的损伤作用,同时观察胍基丁胺对谷氨酸作用的影响,并初步探讨胍基丁胺的作用机制。
- Li, et al separated a molecule from bovine brain cortex that could substitute clonidine and was approved as agmatine (AGM) in 1994. Agmatine is transformed by L-arginine in function of arginine decarboxylase. 1994年Li等从牛脑中分离出一个具有可乐定替代物质特性的分子,研究证实是胍基丁胺(agmatine, AGM)。
- The results suggest that agmatine may inhibit morphine abstinence syndrome,the possible mechanisms include activation of imidazoline receptors,prevention of cAMP up-regulation and over-shooting,and inhibition of NOS activity. 胍丁胺可抑制吗啡的戒断症状,其可能的机制是通过激活咪唑啉受体抑制cAMP的上调和戒断时的超射及抑制NOS的活性。
- It turns out that agmatine can inhibit PC12 cell line DNA injury induced by glutamate through block NMDA-R and improve mitochondrial function and reduce glutamate oxidative toxicity. 这说明胍基丁胺具有抑制PC12细胞DNA损伤的作用,其机制可能与其拮抗NMDA受体,改善线粒体功能和减轻谷氨酸的氧化毒性有关。