After the development of new guidelines for the use of remifentanil in the ICU, a second 12 week study period used an analgesia-based regimen, with hypnotics added only if needed.

• 随着瑞芬太尼在ICU中新的使用指南的出现，之后12周采用以镇痛为基础的疗法，仅在需要时予以催眠药物。