Activation of BRS-3 caused by P3513 may play an important role in protecting HBECs from oxidant injury,and the signal pathway is possibly relevant to Ca~(2+),MEK and PKA.

• P3 5 1 3介导的BRS-3激活对O3应激的HBECs有抗损伤保护作用,其信号途径可能与Ca2+通路、MEK和PKA有关。