Acetylator phenotypes was established by modified Bratton-Marshall procedure and high performance liquid chromatographic (HPLC)method according to percentage of N_4-acetyl-sulfamethazine (Ac-SM_2) in4 to 5-h urine collection (UI_(4-5)).

• 本文使用磺胺二甲嘧啶为探测药物分析乙酰化表型,应用改良Bratton-Mar-shall比色法和高效液相色谱法测定人体尿液中磺胺二甲嘧啶及其代谢物N_4-乙酰磺胺二甲嘧啶。