Abstract Objective:To observe and confirm the specific humoral and cellurar immune responses induced by the nucleic acid vaccinesencoding HBV PreS2+S of subtypes adw and adr and encoding HBcAg in H-2b mice.

• 目的：观察并证实adr和adw亚型MHBs核酸疫苗单独应用，或与HBc核酸疫苗联合免疫诱导H-2b ，小鼠的特异性体液和细胞免疫反应。