AIM: To induce Coxsackie virus B type 3 (CVB3) specific immune response by using a DNA vaccine containing CVB3 VP1 and to observe its protection against CVB3 challenge.

• 目的 :构建表达柯萨奇病毒B3(CVB3)主要包膜蛋白VP1的基因疫苗 ,并研究该疫苗诱导CVB3特异性免疫应答及免疫保护的作用。