AIM: Glomerular hypertrophy and progressive expansion of extracelluar matrix(ECM) have been regarded as the early feature of diabetic nephropathy(DN), which leads to accumulation of mesangium matrix and thickening of glomerular basement membrane(GBM).

• 目的:糖尿病肾病(diabetic nephropathy,DN)早期的病理特征是肾脏肥大和细胞外基质(extracelluar matrix,ECM)的进行性积聚,导致肾小球系膜区细胞外基质成分增加和肾小球基底膜(glomerular basement membrane,GBM)弥漫性增厚。