AGE-BSA induced fractalkine mRNA and protein expression in mesangial cells abundantly which can be inhibited by PDTC and anti-AGE antiboby remarkably.

• AGE诱导体外培养的大鼠系膜细胞大量表达Fkn-mRNA及蛋白,PDTC和AGE抗体显著抑制AGE诱导系膜细胞表达FknmRNA及蛋白。