AA CYP epoxygenase metabolites EETs, could markedly promote endothelial cell proliferation. The effects are mediated by MAP kinase and PI3 kinase/Akt signaling pathways and partially by regulation of eNOS.

• EETs可显著促进BAECs增殖,其作用由ERK和PI3K介导,部分由EETs上调的NO介导。