A novel synthetic method for mono substituted phenylpiperazine from the reaction of phenylbromide with piperazine selectively catalyzed by copper and copper sul-fate without any solvent was developed.

• 报道了无溶剂条件下用铜和硫酸铜作催化剂由溴苯与哌嗪选择性合成单取代苯基哌嗪的新方法,并初步研究了溶剂、反应时间、反应温度对反应产率的影响。