A novel DNA modification discovered in Streptomyces lividans 1326 is different from DNA methylation. This unusual modification causes wild type S. lividans 1326 DNA sensitive to site-specific oxidative double-strand cleavage (Dnd phenotype).

• 野生型变铅青链霉菌具有一种不同于甲基化修饰的新型DNA硫修饰系统，使DNA在电泳时易遭到氧化双链切割而导致降解(Dnd； DNA degradation)表型(Zhou et al.；1988；1994；1999)。