A method was established for determination of losartan potassium and related substances by HPLC. The proposed method was simple, selective, accurate and reproducible.

• 摘要等度洗脱建立了氯沙坦钾原料药的高效液相色谱(HPLC)含量测定方法，方法准确可靠，梯度洗脱建立了氯沙坦钾原料中有关物质的HPLC检查方法。