A consistent estimator is gained by using a method based on the Akaike information criterion(AIC). Two sets of data and Monte Carlo simulation are used to illustrate the method.

• 考虑不会导致风险显著增加的最高剂量；本文使用AIC(Akaike information criterion)方法得到该剂量水平的强相合估计；并且通过两组数据及模拟的结果来说明AIC方法的优良性.