120 patients with CHB and phenotypic lamivudine resistance defined as detectable HBV DNA and elevated ALT levels were enrolled in an observational, retrospective, multicenter study performed in Spain.

• 对拉米夫定耐药的慢性乙肝患者面临着病情恶化甚至死亡的危险。本文的目的就是研究阿德福伟在对拉米夫定耐药的慢性乙肝患者当中使用的安全性和有效性。