[Objectives] Intrahepatic cholestasis of pregnancy (ICP) is a disease that occurs during the second half of pregnancy and dose greate harm to the fetus. The molecular mechanisms of fetal hypoxia signaling in ICP are virtually unexplored.

• [目的] 妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy ICP)是妊娠特有的疾病,对胎儿危害极大,而ICP患者胎儿缺氧的机理目前尚不清楚。