[Object] To investigate the reversal effect of multidrug resistance of human hepatocellular cell (HCC) line of SMMC7721/ADM with antisense RNA of multidrug resistance gene (mdr1) delivered by recombinant adenoviruses.

• 目的 探讨重组腺病毒载体系统AdEasy介导的多药耐药基因(mdr1)反义RNA逆转阿霉素诱导的人肝癌耐药细胞株SMMC7721/ADM的多药耐药性的作用。