[Conclusion] The cisplatin-resistance in human ovarian carcinoma cell lines may be associated with the overexpression of anti-apoptic gene and protein of Bcl-2, Survivin and the downregulation of Caspase-3 and Smac.

• 结论在COC1/DDP中抗凋亡基因及蛋白Bcl-2、Survivin的高表达以及促进凋亡的基因及蛋白Smac和Caspase-3的低表达可能参与COC1/DDP对DDP耐药的发生机制。